Syllabus | GENETICS AND GENOMICS | Second Year | B.Sc Microbiology

SUBJECT: GENETICS AND GENOMICS

S.NO

TOPIC

DOMAIN

HOURS

1

Introduction to mendelian genetics

Mendel’s work on transmission of traits, genetic variation, molecular basis of genetic information. Interrelation between the cell structure and the genetics function. Mitosis, Meiosis (explaining Mendel’s ratios).

Must know

10

Principles of Inheritance, Chromosome theory of inheritance, Pedigree analysis, Incomplete dominance and codominance. Multiple alleles, Lethal alleles, Epistasis, Pleiotropy,

Desirable to know

5

Environmental effects on phenotypic expression, sex linked inheritance. Linkage and crossing over, Interference and coincidence, Somatic cell genetics – an alternative approach to gene mapping.

Nice to know

5

2

Mutation and sex determination: Chromosomal Mutations: Deletion, Duplication, Inversion, Translocation, Aneuploidy and Polyploidy. Gene mutations: Induced versus Spontaneous mutations, Back versus Suppressor mutations,

Must know

12

Molecular basis of Mutations in relation to UV light and chemical mutagens, Detection of mutations: CLB method, Attached X method, DNA repair mechanisms.

Desirable to know

6

Chromosomal mechanisms, Environmental factors effecting sex determination, Barr bodies, Dosage compensation.

Nice to know

2

3

Genetic analysis and genome dynamics: Conjugation; Transformation; Transduction, Recombination. Prokaryotic transposable elements- IS elements,

Must know

10

Composite transposons; Uses of transposons;

Genomics, bioinformatics and proteomics: Human genome project; Evolution and Comparative Genomics. Introduction to Bioinformatics,

Desirable to know

7

Gene and protein databases; Sequence similarity and alignment

Nice to know

3

4

Genomic analysis: Genetic analysis using mutations, forward genetics, genomics, reverse genetics,

 

Must know

8

RNAi, functional genomics and system biology.
Population and evolutionary genetics: Allele frequencies, Genotype frequencies,

Desirable to know

6

Hardy-Weinberg Law, role of natural selection, mutation, genetic drift. Genetic variation and Speciation

Nice to know

6

Suggested readings:

  1. Gardner, E.J., Simmons, M.J., Snustad, D.P. (2008). VIII ed. Principles of Genetics. Wiley India.
  2. Snustad, D.P., Simmons, M.J. (2009). Principles of Genetics. V Edition. John Wiley and Sons Inc.
  3. Klug, W.S., Cummings, M.R., Spencer, C.A. (2009). Concepts of Genetics. XI
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Admission 2017
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